Robust optimal control of a biochemical reactor with multiple objectives


  • F. Logist, B. Houska, M. Diehl, J. Van Impe


  • Computer Aided Chemical Engineering,
    Volume 29, pages 1460 - 1464, 2011.


This paper studies the optimal control of a fed-batch fermentor with conflicting productivity and yield objectives under uncertainty. To generate the robustified Pareto sets for different uncertainty levels, a novel scalarisation based multi-objective approach (i.e., normalised normal constraint) is combined with a recent linearisation based robust optimal control approximation method. This combination allows the use of fast gradient based optimisation routines and ensures an accurate and efficient Pareto set generation.



author = {F. Logist and B. Houska and M. Diehl and J. Van Impe},
title = {Robust optimal control of a biochemical reactor with multiple objectives},
journal = {Computer Aided Chemical Engineering},
year = {2011},
volume = {29},
pages = {1460–1464}